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Check out Spezial-K on Beatport. Genre(s) · Hip-Hop. Gründung, Aktuelle Besetzung. Rap. Spezial-K. Rap. MC Algun. Kurzer Prozess ist eine anarchistische Punkrap-Band aus Nürnberg. In ihren Texten. Okt. bassverstärker versus wasserwerfer“– rap. auflegen. graffiti. fotos und gedankengänge.{/PREVIEW}

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Other drugs which increase blood pressure may interact with ketamine in having an additive effect on blood pressure including: Increase blood pressure and heart rate, palpitations, and arrhythmias may be potential effects.

Ketamine may increase the effects of other sedatives in a dose-dependent manner, including, but not limited to alcohol , [81] benzodiazepines , [82] opioids , [83] quinazolinones , phenothiazines , anticholinergics , and barbiturates.

Benzodiazepines may diminish the antidepressant effects of ketamine. In vitro , ketamine acts as a selective antagonist of the NMDA receptor , an ionotropic glutamate receptor.

Besides NMDA receptor antagonism, other actions of ketamine under laboratory research include: Ketamine has been found to act as a potent partial agonist of the high-affinity state of the human and rat dopamine D 2 receptors in multiple studies.

Antagonism of the NMDA receptor is thought to be responsible for the anesthetic, amnesic , dissociative, and hallucinogenic effects of ketamine.

Ketamine produces measurable changes in peripheral organ systems, including the cardiovascular , gastrointestinal , and respiratory systems: It has yet to be fully understood how ketamine mediates its robust and rapid-onset antidepressant effects.

Drowsiness , dissociation , and psychosis -like effects e. In medical settings, ketamine is usually injected intravenously or intramuscularly.

Oral ketamine is easily broken down by bile acids, thus has a low bioavailability. Often, lozenges or "gummies" for sublingual or buccal absorption prepared by a compounding pharmacy are used to combat this issue.

Some specialists stop the subcutaneous infusion when the first dose of oral ketamine is given. Others gradually reduce the infusion dose as the oral dose is increased.

Ketamine is absorbable by intravenous , intramuscular , oral , and topical routes due to both its water and lipid solubilities.

Dehydronorketamine, followed by norketamine, is the most prevalent metabolite detected in urine. In chemical structure, ketamine is an arylcyclohexylamine derivative.

Ketamine is a chiral compound. Most pharmaceutical preparations of ketamine are racemic ; however, some brands reportedly have mostly undocumented differences in their enantiomeric proportions.

The more active enantiomer, esketamine S -ketamine , is also available for medical use under the brand name Ketanest S, [] while the less active enantiomer, arketamine R -ketamine , has never been marketed as an enantiopure drug for clinical use.

The optical rotation of a given enantiomer of ketamine can vary between its salts and free base form. The difference originates from the conformation of the cyclohexanone ring.

In both the free base and the hydrochloride, the cyclohexanone ring adopts a chair conformation , but the orientation of the substituents varies.

In the free base, the o -chlorophenyl group adopts an equatorial position and the methylamino group adopts an axial position. Ketamine may be quantitated in blood or plasma to confirm a diagnosis of poisoning in hospitalized patients, provide evidence in an impaired driving arrest or to assist in a medicolegal death investigation.

Blood or plasma ketamine concentrations are usually in a range of 0. Urine is often the preferred specimen for routine drug use monitoring purposes.

The presence of norketamine, a pharmacologically-active metabolite, is useful for confirmation of ketamine ingestion. Ketamine was first synthesized in by Calvin L.

Stevens , a professor of Chemistry at Wayne State University and a Parke-Davis consultant conducting research on alpha-hydroxyimine rearrangements.

Nonmedical use of ketamine began on the West Coast of the United States in the early s. Ketamine is primarily sold throughout the world under the brand name Ketalar.

Esketamine is sold mainly under the brand names Ketanest and Ketanest-S. After the publication of the NIH-run antidepressant clinical trial, clinics began opening in which the medication is given.

While ketamine is legally marketed in many countries worldwide, [] it is also a controlled substance in many countries.

In Australia Ketamine is listed as a schedule 8 controlled drug under the Poisons Standard October In Canada , ketamine is classified as a Schedule I narcotic, since By , ketamine was classified as class III in Taiwan ; given the recent rise in prevalence in East Asia, however, rescheduling into class I or II is being considered.

In December , the government of India , in response to rising recreational use and the use of ketamine as a date rape drug, has added it to Schedule X of the Drug and Cosmetics Act requiring a special license for sale and maintenance of records of all sales for two years.

Recreational use of ketamine was documented in the early s in underground literature e. Consignments of Ecstasy known as "Strawberry" contained what Saunders described as a "potentially dangerous combination of ketamine, ephedrine , and selegiline ", as did a consignment of "Sitting Duck" Ecstasy tablets.

The use of ketamine as part of a "post-clubbing experience" has also been documented. Ketamine use as a recreational drug has been implicated in deaths globally, with more than 90 deaths in England and Wales in the years of — It takes effect within about 10 minutes, [] while its hallucinogenic effects last 60 minutes when insufflated or injected and up to two hours when ingested orally.

Lilly , Marcia Moore and D. Turner amongst others have written extensively about their own entheogenic use of, and psychonautic experiences with ketamine.

Because of its ability to cause confusion and amnesia , ketamine has been used for date rape. Production for recreational use has been traced to , when it was referred to as "mean green" and "rockmesc".

According to the ongoing Monitoring the Future study conducted by University of Michigan , prevalence rates of recreational ketamine use among American secondary school students grades 8, 10, and 12 have varied between 0.

In , the U. While most of Canada sees ketamine use roughly on par with other Western nations, the Toronto region has been known as an epicentre for ketamine use in the West.

In China, the small village of Boshe in eastern Guangdong was confirmed as a main production centre when it was raided in Established by the Hong Kong Narcotics Division of the Security Bureau , the Central Registry of Drug Abuse CRDA maintains a database of all the illicit drug users who have come into contact with law enforcement, treatment, health care, and social organizations.

The compiled data are confidential under The Dangerous Drugs Ordinance of Hong Kong, and statistics are made freely available online on a quarterly basis.

A survey conducted among school-attending Taiwanese adolescents reported prevalence rates of 0. Russian doctor Evgeny Krupitsky has claimed to have encouraging results by using ketamine as part of a treatment for alcohol addiction which combines psychedelic and aversive techniques.

In veterinary anesthesia , ketamine is often used for its anesthetic and analgesic effects on cats, [] dogs, [] rabbits , rats , and other small animals.

It is an important part of the " rodent cocktail ", a mixture of drugs used for anesthetizing rodents. Ketamine is used to manage pain among large animals, though it has less effect on bovines.

From Wikipedia, the free encyclopedia. For the functional group referred to as ketimine, see imine. C Risk not ruled out. Skeletal formula of R -ketamine.

Ball-and-stick model of R -ketamine. Reinforcement and Addictive Disorders". A Foundation for Clinical Neuroscience 2nd ed. Phencyclidine PCP or angel dust and ketamine also known as special K are structurally related drugs Cochrane Database of Systematic Reviews.

Ketamine for Treatment-Resistant Depression: The First Decade of Progress. Archived from the original on 8 September The Complete Drug Reference".

Retrieved 24 August Hall 6 December Concise Dictionary of Pharmacological Agents: Archived from the original on 11 April Drug Metabolism and Disposition.

Toxicological Aspects of Drug-Facilitated Crimes. Handbook of Experimental Pharmacology. Continuous Subcutaneous Infusions in Palliative Care.

Pharmacology and Therapeutics for Dentistry — E-Book. Principles of Forensic Toxicology. Archived from the original on 10 December Retrieved 1 December Annals of Emergency Medicine.

Center for Substance Abuse Research. Archived from the original on 12 November Retrieved 26 September American Journal of Emergency Medicine.

Archived from the original on 18 August Archived PDF from the original on 13 December Retrieved 8 December Archived from the original on 23 August Retrieved 12 January Current applications in anesthesia, pain, and critical care".

Anesthesia, Essays and Researches. Iranian Journal of Allergy, Asthma, and Immunology. Archived from the original on 6 October Life in the Fastlane blog.

Archived from the original on 9 February Retrieved 10 April Frequency, duration, and consequences". Circulatory interactions during total intravenous anesthesia and analgesia-sedation].

Der Anaesthesist in German. Expert Review of Respiratory Medicine. Indian Journal of Critical Care Medicine. Archived from the original on 8 August Pain, Palliative and Supportive Care Group.

Cochrane Database of Systematic Reviews 1: A quantitative systematic review of randomised trials". A systematic review and synthesis of the literature".

A retrospective analysis of a novel therapeutic approach to complex regional pain syndrome". Cochrane Database Syst Rev 9: Annual Review of Medicine.

Therapeutic Advances in Psychopharmacology. Expert Opin Investig Drugs. Expert Review of Neurotherapeutics. Australian Medicines Handbook Pty Ltd.

Anderson, Cliff June Archived from the original on 17 December Current Opinion in Anesthesiology. A 1-year longitudinal study".

Insight into molecular mechanisms and relevance to humans". Psychotomimetic, perceptual, cognitive, and neuroendocrine responses".

Archives of General Psychiatry. A literature review" Submitted manuscript. International Journal of Clinical Practice.

Current Opinion in Supportive and Palliative Care. Potential Pharmacokinetic and Pharmacodynamic Drug Interactions". The Journal of Clinical Psychiatry.

Archived from the original on 14 July Perspectives in Clinical Research. Archived from the original on 5 May Retrieved 14 August Insights into Therapeutic Mechanisms".

Journal of Pharmacology and Experimental Therapeutics. D2 basis for schizophrenia". The International Journal of Neuropsychopharmacology.

British Journal of Anaesthesia. British Journal of Pharmacology. Its mechanism s of action and unusual clinical uses". Archived from the original on 20 October The Journal of Neuroscience.

Teaching an old drug new tricks". Australian Medicines Handbook 12th ed. International Journal of Psychiatry in Clinical Practice.

A report of two cases". European Journal of Pharmacology. Reevaluation of an old drug". The Journal of Clinical Pharmacology.

Trends in Anaesthesia and Critical Care. Drug and Alcohol Dependence. August [August ]. Archived from the original PDF on 29 October An update on licit and illicit ketamine use".

Substance Abuse and Rehabilitation. A review of its pharmacologic properties and use in ambulatory anesthesia". Anaesthesiologie und Reanimation in German.

Journal of Separation Science. Acta Crystallographica Section E. Drug Testing and Analysis. Development of a gas chromatography-mass spectrometry method for determination of ketamine in plasma and its application to human samples.

Detection of ketamine and its metabolites in urine by ultra high pressure liquid chromatography-tandem mass spectrometry. Chronic Pain and Addiction.

The diet has been criticised for being too low in protein , fiber , vegetables, and fruits. The diet does not include guidance on how to change unhealthy overeating or lack of exercise and their importance to permanent weight loss.

One serving contains 0. In the UK, an advertising campaign has focused on the results of a study run in collaboration with the Department of Human Sciences at Loughborough University , requiring overweight volunteer subjects to replace two meals a day with a bowl of the cereal.

In the US, Special K cereal currently comes in fourteen different varieties: Ingredients in Special K include: Vitamins and minerals include vitamin C ascorbic acid , vitamin E alpha tocopherol acetate , niacinamide, reduced iron, vitamin B 6 pyridoxine hydrochloride , vitamin B 1 thiamin hydrochloride , vitamin A palmitate , vitamin B 2 riboflavin , folic acid , and vitamin B In the US, Special K provides meal replacements in two different forms, protein meal bars and protein shakes.

There are eight varieties of Special K Protein Shakes: There are five varieties of Special K Breakfast Shakes: There are two varieties of Special K Cereal Bars: Red Berries, and Chocolatey Pretzel.

There are five varieties of Special K Cracker Chips: There are two varieties of Special K Popcorn: Kettle Corn and White Cheddar.

There is one variety of Special K Crackers: It was produced in several flavors and has been marketed as a weight-control and weight-loss product.

The product was re-launched in by the Kellogg Company. The product is no longer available. The product was also manufactured in a powdered form as a drink mix that is sold in packets, which is then added to water.

Skinny is not how she wants to be perceived, but rather, strong. Young children risk liver and kidney damage while the fetuses of pregnant women could suffer complications.

The show provided evidence that the iron was not nutritional ionic iron—as it occurs in natural foods like spinach—but was, in fact, metallic iron.

The nutritional experts in the show agreed that metallic iron should not be part of a diet. Metallic iron is speculated to damage organs.

They also challenged the claim that the cereal could contain "shredded bites," and responded that iron powder is suitable for human consumption.

Babu George, Sacred Heart University, in which iron is extracted from cereals. As a result of this experiment being published and inquiries being made to the manufacturers, some companies have replaced the metallic iron in their products with an iron compound such as iron III phosphate, ferric phosphate.

The reason behind the extra crunch is the additional ingredient, barley. Kellogg shoppers also complained that the cereal has become too sugary.

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